Garlic Parmesan Chicken Spaghetti in Spicy Cajun Cream Sauce

You know those meals that stop conversation at the dinner table? The ones that make people pause mid-bite and say, “Whoa… what is THIS?” That’s exactly what this Garlic Parmesan Chicken Spaghetti in Spicy Cajun Cream Sauce delivers. Creamy, cheesy, spicy, and loaded with bold flavor—it’s the kind of pasta that doesn’t just satisfy hunger… it craves repeat appearances.

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What Is Garlic Parmesan Chicken Spaghetti in Spicy Cajun Cream Sauce?

This dish is a creamy, spicy, flavor-packed pasta where juicy, golden chicken meets a dreamy sauce made with garlic, parmesan cheese, Cajun seasoning, and heavy cream. Toss in a generous serving of spaghetti and boom—you’ve got a bold, Southern-inspired pasta dish that’s ready to impress.

It’s like Alfredo’s fiery Cajun cousin—with all the comfort of creamy pasta and none of the bland.

Why You’ll Love This Recipe

• Big bold flavors: Garlic, Cajun spice, parmesan, and cream all in one dish
• Restaurant-quality at home
• Customizable heat levels to suit your preference
• Perfect weeknight dinner in under 45 minutes
• Even better as leftovers (if you have any!)

What Does It Taste Like?

This pasta hits all the right notes. The garlic and parmesan give it depth and richness, the Cajun seasoning brings the heat and smoky flavor, and the chicken adds heartiness. The sauce is creamy, cheesy, slightly spicy, and completely addictive. Every forkful is full of flavor and texture—comfort food with a serious kick.

Benefits of Making This Recipe

• One-pan sauce, one-pot pasta
• Feeds a crowd (or makes great leftovers)
• Can be made gluten-free or dairy-free with a few swaps
• Easy to adjust the spice level
• Packed with protein and customizable veggies

Ingredients for Garlic Parmesan Chicken Spaghetti in Spicy Cajun Cream Sauce

For the chicken:

• 1 lb boneless, skinless chicken breast or thighs
• 1 tablespoon olive oil
• 1 tablespoon Cajun seasoning (store-bought or homemade)
• Salt and pepper, to taste

For the sauce:

• 3 tablespoons butter
• 4 cloves garlic, minced
• 2 teaspoons Cajun seasoning
• 1/2 teaspoon smoked paprika
• 1/2 teaspoon red pepper flakes (optional for extra heat)
• 1 1/4 cups heavy cream
• 3/4 cup freshly grated parmesan cheese
• Salt and pepper, to taste
• Optional: splash of chicken broth to thin the sauce

For the pasta:

• 12 oz spaghetti (or pasta of your choice)
• 1/2 cup reserved pasta water
• Fresh parsley or green onions, for garnish

Optional add-ins:

• Sautéed bell peppers or mushrooms
• Spinach or kale for a veggie boost
• Crumbled bacon (because… yes.)

Tools You’ll Need

• Large pot for boiling pasta
• Large skillet or sauté pan
• Tongs or spatula
• Whisk
• Cheese grater
• Measuring cups and spoons

Ingredient Additions & Substitutions

• Less spicy? Use mild Cajun seasoning and skip the red pepper flakes
• Make it extra spicy? Add cayenne or hot sauce to the sauce
• Dairy-free option: Use coconut cream and dairy-free parmesan
• Gluten-free? Use GF spaghetti and check your seasoning mix
• No chicken? Try shrimp, sausage, or tofu instead

How to Make Garlic Parmesan Chicken Spaghetti in Spicy Cajun Cream Sauce

1. Boil your pasta: Cook the spaghetti according to package directions in salted water until al dente. Reserve 1/2 cup pasta water, then drain and set aside.
2. Season and cook the chicken: While the pasta cooks, season chicken with Cajun seasoning, salt, and pepper. Heat olive oil in a large skillet over medium-high. Cook chicken for 6–8 minutes per side, until golden and cooked through. Remove and let rest, then slice.
3. Make the Cajun garlic parmesan cream sauce:
   • In the same skillet, melt butter.
   • Add garlic and cook for 1 minute until fragrant.
   • Stir in Cajun seasoning, smoked paprika, and red pepper flakes.
   • Slowly pour in the heavy cream and whisk until combined.
   • Stir in parmesan cheese and let simmer until thickened (about 3–5 minutes).
   • Season with salt and pepper to taste.
4. Combine everything: Add cooked spaghetti to the sauce, along with a splash of reserved pasta water to loosen if needed. Toss to coat.
5. Add sliced chicken: Place the sliced chicken back on top or stir it in, and garnish with chopped parsley or green onions.
6. Serve hot: Top with extra parmesan and a dash of Cajun seasoning if you’re feeling bold!

What to Serve with Cajun Chicken Spaghetti

• Garlic bread or cheesy toast
• Side salad with a tangy vinaigrette
• Grilled or roasted veggies like asparagus or zucchini
• A cold beer or iced tea to balance the spice

Tips for Creamy, Flavor-Packed Pasta

• Use freshly grated parmesan—pre-shredded doesn’t melt as smoothly
• Don’t overcook the chicken—it should be juicy, not dry
• Adjust the Cajun seasoning to your heat level
• Add pasta water slowly—it’s your secret sauce thickener
• Let the chicken rest before slicing for maximum juiciness

Storage Instructions

• Fridge: Store in an airtight container for up to 4 days
• Reheat: Warm on the stove or in the microwave with a splash of cream or milk
• Freezer: Not ideal due to the cream sauce—it may separate

Frequently Asked Questions

Can I use rotisserie chicken?

Yes! Just skip the cooking step and warm it in the skillet with Cajun seasoning before adding the sauce.

Can I use a different pasta?

Absolutely. Penne, fettuccine, or rigatoni all work beautifully.

Is this recipe spicy?

It has a gentle heat, but you control it! Dial it up or down with the amount of Cajun seasoning and pepper flakes.

Can I make it vegetarian?

Yes! Use sautéed mushrooms, roasted veggies, or tofu instead of chicken.

Conclusion

When you want a pasta dish that brings the heat, the creaminess, and the kind of flavor that makes people ask for seconds, this Garlic Parmesan Chicken Spaghetti in Spicy Cajun Cream Sauce has your back. It’s bold, comforting, and unforgettable—basically your new weeknight hero.

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