Thank you so much for stopping by! If you’ve been searching for a comforting, creamy pasta dish that brings bold flavor with every forkful, this one’s for you. This Creamy Cajun Chicken Spaghetti with Mozzarella Velveeta Alfredo Sauce is a rich and spicy twist on a Southern comfort classic—loaded with tender chicken, gooey melted cheese, and that Cajun kick we all crave.
Whether you’re feeding a crowd or just looking for a weekday dinner that’ll leave everyone asking for seconds, this recipe checks every box. And yes—there’s mozzarella, Velveeta and Alfredo sauce. This is not a drill.
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What Is Creamy Cajun Chicken Spaghetti?
This dish is the ultimate mashup: smoky, spicy Cajun-style chicken tossed with spaghetti noodles, all coated in a luscious Alfredo-style cheese sauce made from melty Velveeta, gooey mozzarella, and rich cream. It’s creamy, cheesy, and full of bold Louisiana flavor.
Think of it as the soul food cousin of chicken Alfredo—with a little extra sass!
Why You’ll Love This Recipe
- Bold Cajun flavor with creamy, cheesy comfort
- One-pot-ish meal (the sauce comes together fast!)
- Kid-friendly but easily adjustable for spice lovers
- Easy to customize with veggies, proteins, or pasta shapes
- Great for leftovers—it reheats like a dream
What Does It Taste Like?
Creamy, smoky, spicy, cheesy—everything you want in a comfort dish. The Cajun seasoning brings a slightly peppery, garlicky depth, while the Velveeta and mozzarella give it that silky, melty texture that coats the spaghetti perfectly. It’s rich, indulgent, and so satisfying.
The chicken adds a savory, juicy bite that makes this dish feel hearty enough to stand on its own. Basically? It tastes like a hug in a bowl… with a bit of a kick.
A Comfort Food with Benefits
Okay, so it’s not exactly “light”—but it is:
- Protein-packed from the chicken and cheese
- Totally flexible—sneak in spinach, mushrooms, or bell peppers!
- Make-ahead friendly for busy nights or meal prep
Ingredients
For the Chicken:
- 2 large chicken breasts, sliced thin or cubed
- 1 tablespoon olive oil
- 1½ tablespoons Cajun seasoning (homemade or store-bought)
- Salt & pepper, to taste
For the Pasta & Sauce:
- 12 oz spaghetti (or any pasta you love)
- 2 tablespoons butter
- 3 cloves garlic, minced
- 1½ cups heavy cream
- 1½ cups shredded mozzarella cheese
- 6 oz Velveeta cheese, cubed
- ¼ cup grated Parmesan cheese (optional for depth)
- ½ teaspoon paprika
- ½ teaspoon Cajun seasoning (for the sauce)
- Salt & pepper, to taste
Optional Toppings:
- Chopped parsley or green onions
- Crushed red pepper flakes
- Extra Cajun seasoning dusted on top
Tools You’ll Need
- Large pot (for pasta)
- Deep skillet or sauté pan
- Knife and cutting board
- Cheese grater
- Wooden spoon or spatula
Ingredient Additions & Substitutions
- Add veggies: Sautéed bell peppers, spinach, mushrooms, or broccoli all work great.
- Use rotisserie chicken: Save time with pre-cooked shredded chicken.
- Swap pasta: Penne, fettuccine, or even shells hold the sauce beautifully.
- Make it spicier: Add cayenne or hot sauce to taste!
- Go lighter: Use light cream or half-and-half, and reduced-fat cheese.
How to Make Creamy Cajun Chicken Spaghetti
Step 1: Cook the Pasta
Bring a large pot of salted water to a boil. Cook spaghetti according to package instructions until al dente. Drain and set aside, reserving ½ cup pasta water.
Step 2: Season & Cook the Chicken
In a large skillet, heat olive oil over medium-high heat. Season chicken pieces generously with Cajun seasoning, salt, and pepper. Cook for 5–7 minutes until fully cooked and golden brown. Remove and set aside.
Step 3: Make the Sauce Base
In the same skillet, melt butter and sauté garlic until fragrant (about 1 minute). Add heavy cream and stir well. Let it simmer gently for 2–3 minutes to thicken slightly.
Step 4: Add the Cheese
Reduce heat to low. Stir in Velveeta cubes, mozzarella, Parmesan (if using), paprika, and a little more Cajun seasoning. Stir constantly until everything melts into a smooth, creamy sauce. If it’s too thick, add a splash of reserved pasta water.
Step 5: Combine Everything
Add cooked spaghetti and chicken to the skillet. Toss gently to coat everything in that glorious sauce. Taste and adjust seasoning if needed.
Step 6: Garnish & Serve
Top with fresh parsley, red pepper flakes, or extra cheese if desired. Serve immediately while it’s hot and melty!
What to Serve With Cajun Chicken Spaghetti
This dish is rich, so pair it with something fresh or light:
- Garlic bread (because carbs deserve company)
- Simple green salad with vinaigrette
- Roasted veggies like asparagus or zucchini
- Cornbread muffins for a Southern twist
Tips for Success
- Use room-temperature cheese for easier melting
- Cook pasta just shy of al dente—it’ll finish in the sauce
- Don’t walk away from the sauce! Stir frequently to prevent scorching
- Add pasta water gradually to loosen the sauce without thinning it too much
- Double the batch—this reheats beautifully for meal prep or next-day lunches
Storage Instructions
- Refrigerate leftovers in an airtight container for up to 4 days.
- Reheat on the stovetop with a splash of milk or cream to restore creaminess.
- Freeze? It’s best fresh, but you can freeze it (expect a slight texture change). Wrap tightly and use within 1 month.
General Info About Cajun Creamy Pasta Dishes
Cajun cream-based pasta dishes are Southern-inspired meals that fuse French and Creole flavors—smoky paprika, garlic, onion, and cayenne—with luxurious, cheesy cream sauces. They’re hearty, indulgent, and often made with chicken, shrimp, or sausage. This recipe takes that soul-warming idea and turns it into something family-friendly and absolutely unforgettable.
Frequently Asked Questions
Can I use store-bought Alfredo sauce?
Yes! Stir in 1 jar of Alfredo sauce with the cheese and add Cajun seasoning to taste.
Can I make it ahead of time?
Yes—just store the pasta and sauce separately if possible, then combine and reheat when ready.
What if I don’t have Velveeta?
Use more mozzarella and a bit of cream cheese for that melt factor, or shredded cheddar for a sharper taste.
Is this spicy?
Mild to medium, depending on your Cajun seasoning. Adjust heat by adding or reducing spice levels.
Can I make it vegetarian?
Absolutely! Omit the chicken and add mushrooms or roasted cauliflower for a hearty veg version.
Conclusion
This Creamy Cajun Chicken Spaghetti with Mozzarella Velveeta Alfredo Sauce is comfort food done right. It’s cheesy, spicy, satisfying, and just a little indulgent—in all the best ways. Whether you’re cooking for a hungry family or meal-prepping your lunches for the week, this is one recipe you’ll keep coming back to.